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About LIPOSOMA

HOME \ About LIPOSOMA

LIPOSOMA

High-end liposomal supplements

Liposome technology is LIPOSOMA’s core business. Based at Amsterdam innovation hot spot Science Park, LIPOSOMA is the result of years of scientific liposome research. We serve our global customers with state-of-the-art liposome technology and quality control equipment and at a competitive price.

Visit Liposomatechnology.com for more corporate information and LIPOSOMA’s three divisions.

Image of Science park building where Liposoma is located

Our Story

Asha van Rooijen founded LIPOSOMA in 2013 to bring Clodronate Liposomes, a research tool for immunological research, to the market. Clodronate Liposomes were developed by Nico van Rooijen and are used worldwide to study various models of autoimmune diseases, transplantation, neurological disorders and gene therapy. By investing an overwhelming share of revenues in research & development, Asha and her team expanded LIPOSOMA’s activities in a wide range of industries, ranging from immunological research to vitamin supplements and medical nutrition. It is LIPOSOMA’s mission to be a world leading lipid nanoparticle based company, guaranteed by its commitment to scientific excellence. Currently LIPOSOMA provides liposomal and other lipid based products as a CMO and branded label provider, offering platform technology for a wide range of human health products.

Our history

By the late 1990s, Nico van Rooijen had made a name for himself as a developer of clodronate liposomes. It was the operation of the human immune system that fascinated him most of all, and after achieving a PhD in cell biology in 1974, he devoted his scientific career to research into the immune system. He was particularly interested in the role played by macrophages in the spleen – a truly remarkable organ with several important physiologic and immunologic functions.

Finding practical applications for scientific research

Dr Van Rooijen explains: “The word ‘macrophage’ comes from ancient Greek for ‘large eater’. You can see them as the ‘vacuum cleaners’ of the body, clearing away waste products. The complex immune system with the wide array of immune cells that we have today did not develop until much later in our evolutionary history.”

Rapid development

Over the course of evolution, macrophages came to take on a wide variety of functions. In order to understand exactly which roles were being played by macrophages, Dr Van Rooijen wanted to find a way of switching off one type of macrophage at a time in order to see which function would be affected. “But there were no adequate research methods for doing this at that time”, he clarifies. 

However, that all changed when Dr Van Rooijen learned of ground-breaking work being done by the British researcher Alec Bangham and his colleague Gregory Gregoriadis. This allowed him to make rapid progress in his own research.

Liposome discovery

Alec Bangham was the first person to identify the structure of a liposome. He discovered  when phospholipids of natural origin mix with water, the molecules arrange themselves into concentric, bi-layered vesicles enclosing an aqueous interior. Gregory Gregoriadis went on to discover that a liposome could also be used as an ‘ultra-small transport and delivery vehicle’ for medical purposes or for other uses such as liposomal supplements.

Clodronate liposomes

“When I came across this work, I saw new possibilities for my own research,” explains Dr Van Rooijen. “If I could make a liposome which contained an active substance that was toxic to a particular type of macrophage in the spleen, the macrophage would consume the liposome and would die as a result. I used one particular type of liposome to do this, the ‘clodronate’ liposome. We called this method the liposome-mediated macrophage suicide approach. From the start it was clear to me that this approach could be applied well beyond the area of spleen research.”

Image of a Liposome

Towards an Amsterdam-based liposome venture

Nico van Rooijen’s research at Vrije Universiteit Amsterdam caught the attention of research institutes all over the world. “We had to set up an academic production unit in order to meet the demand for clodronate liposomes. Because there was so much demand for information about liposomes, my role became more strictly limited to advice and guidance. At some point the time was ripe to spin out our liposome technology and expertise into a new Amsterdam-based commercial venture called LIPOSOMA BV. My son Ashwin – and later my daughter Asha – played a pivotal role in turning this into a flourishing business but with strong academic ties.”

Expanding at Science Park Amsterdam

Asha van Rooijen decided to further expand LIPOSOMA’s business with liposome expertise and technology for research, medical applications and liposomal supplements. She set up a laboratory and a production unit at Science Park in Amsterdam and involved Prof Gert Storm of Utrecht University, a well-known liposome expert with a strong background in pharmaceutical and medical application. Asha explains: “Clodronate liposomes were really just a research tool – good for science. But I wanted to see liposome technology being applied not just in a research environment but also for the benefit of human health. In early 2017, I met these two liposome scientists, not only Prof Storm but also Dr Bart Metselaar, who clinically develops liposome products encapsulating therapeutic agents for better treatment of patients. Since then, we have been working on making liposome technology more widely available for many different clients and purposes such as liposomal vitamin supplements.”

Synergy

Indeed, Dr Van Rooijen’s work has been taken forward through familial cross-fertilisation, his son Ashwin using modern IT methods and his entrepreneurial daughter Asha expanding the application of liposome technology in the field of health and liposomal supplements. Asha explains: “All three of us – my father, my brother and I – have played an essential role in getting to where we are today. We are continuing and expanding liposome research and contract manufacturing on demand for research purposes and health products. ”Dr van Rooijen adds: “It’s wonderful to see how my research has led to actual real-life applications.”

Divisions

In addition to our liposome nutraceutical division, LIPOSOMA also has a Research liposomes and a research & manufacturing division:

  • LIPOSOMA’s research liposomes division supplies liposomes to many universities worldwide for the purpose of scientific research into auto-immune diseases, transplantation, and neurological disorders.
  • LIPOSOMA‘s research & manufacturing division can take all your questions and requests related to your current and future custom-made liposomal products with our liposome research and contract manufacturing.

Would you like to learn more? Give us a call at 0031 20 237 36 00

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Contact us

Logo Liposoma Nutraceuticals

    LIPOSOMA HEALTH

  • Science Park 408
  • 1098 XH AMSTERDAM
  • The Netherlands
  • VAT: NL8524.12.551.B01
  • Commercial Chamber: 73881155
  • Phone: +31 (0)20 237 3600
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NOW AVAILABLE

White Label Liposomal Vitamin D3

Order now before February 28, 2021
Available:as finished product capsules and liquid or bulk capsules.
Lead Time6 weeks, MOQ 1000 jars.