We are the first to offer PEA in a high-quality and directly applicable format for unique end products
PEA in Nutra cups
Liposoma proudly announces our newest product range, called Nutra cups. For Liposoma’s Nutra cups we selected our finest liposome ingredients and placed these in cup cartridges that are designed for standard coffee cup extraction machines, which are present in almost every household. Every Nutra cup produces a perfect liposome dispersion upon hot water extraction, containing high-quality active ingredients. This technology is especially well suited for active ingredients that require higher daily doses, like palmitoylethanolamide (PEA), a substance that can be very helpful in peripheral pain relief. PEA requires a high starting dosage of 1200 mg per day, followed after two months by a daily maintenance dosage of 600 mg, which can be provided because of our Nutra cup technology. Orally administered PEA in the form of capsules containing conventional powder is poorly absorbed by the body. The warm liposomal PEA dispersion produced with PEA Nutra cups ensures PEA is optimally encapsulated in finely dispersed liposome vesicles, facilitating the process of intestinal uptake and leading to more effective concentrations in the body. Moreover, because the actual liposome dispersion is produced at home right before consumption, no preservatives are needed in the product.
What is PEA?
Palmitoylethanolamide (PEA) is an endogenous lipid present in various human tissues including the brain, liver, eyes and muscles. It is produced from membrane phospholipids and exerts a variety of functions, many of which are related to inflammation and pain signalling . Abnormalities in the levels of PEA are associated with chronic inflammation  and pain disorders [3,4,5] underlining its importance in these processes.
PEA and pain reduction
A substantial number of preclinical and clinical studies have demonstrated that PEA administration can relieve pain (analgesia). Two meta-analyses of these studies both concluded that PEA treatment was indeed associated with significant pain reduction. Efficacy is reported in lower back pain, Carpal Tunnel Syndrome and pelvic pain [6,7]. More recent clinical studies confirm the analgesic efficacy of PEA in the treatment of patients with bladder pain syndrome , chronic pelvic pain , chronic orofacial pain , (chronic) lower back pain [11-14], Carpal Tunnel Syndrome , knee osteoarthritis , diabetes  and pain after back or spine surgery .
Several different mechanisms of action have been suggested to explain the analgesic effects of PEA. Firstly, PEA can modulate the activity of the endocannabinoid system, which plays a key role in the experience of pain . PEA does not directly bind to cannabinoid receptors but modulates their activity indirectly by preserving the natural agonists of these receptors [20,21]. Secondly, PEA reduces inflammation in the peripheral and central nervous system, which also leads to chronic pain relief [22-24].
Limitations of other PEA products
Due to its lipophilic nature and high melting point, PEA is barely soluble in water and other aqueous solvents . Upon oral intake of a typical dose of PEA in conventional powder form, very little is absorbed and enters the blood circulation, leaving only minimal amounts that can reach the target sites in the human body. Several attempts to improve this have been made, but the tendency of PEA molecules to crystallize and precipitate in almost every solubilization attempt, points to the difficulty also the body faces in absorbing the PEA molecules from the intestinal lumen and transporting it to the target sites. Indeed, the bioavailability of PEA in humans seems to be extremely low with only a short-lived presence in blood after oral intake [26, 27].
Benefits of Nutra cups
By providing PEA in a liposome, bioavailability can be increased compared to non-liposomal PEA products. To enable successful liposomal encapsulated PEA, Liposoma developed a new technology called Nutra cups. With this technology, all ingredients of liposomal PEA are provided in a cup cartridge and liposomes are formed upon extraction of the cups with warm water. The cups are made compatible with standard coffee cup extraction machines, so that the liposomal PEA beverage can be produced at home right before consumption. At Liposoma we discovered that only this way complete dissolution of the PEA molecules in the liposomal vesicles can be ensured and the required dose can be administered. Furthermore, the Nutracups technology has the advantage that no preservatives are needed.
To summarize, with our Nutra cups liposomal PEA product we provide you an effective dose of PEA in the best available form to enable your body to benefit from its health effects that have been studied and documented by many scientists all over the world.
“Discover all the benefits of our liposome technology that along with our outstanding ingredients help us to establish valuable relationships with our business partners. “
Liposoma Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
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