DHA and Lutein are loaded into the liposomes to make them work synergistically, providing a unique combination for vision health
Liposomal DHA-Lutein supports vision health
Our high-end liposomal DHA-Lutein supplement is superior in terms of absorption and effectiveness due to our proprietary formulation process and liposome technology.
What is lutein?
Lutein is a naturally occurring carotenoid that, together with zeaxanthin, constitutes the macula of the eye, the region responsible for clear, central vision and colour perception [1,2]. Lutein absorbs blue light and thereby protects the eye from light induced damage. In addition, the carotenoid acts as an antioxidant: it reduces the number of harmful oxygen intermediates that can impair eye function . In its standard form, very little of a typical dose of lutein gets absorbed by the human body.
Health effects of lutein
Since lutein is not produced endogenously, it must be consumed from our diet . Among others, it can be found in fruits and vegetables as well as egg yolk [5,6]. The intake of sufficient amounts of lutein is important in maintaining eye health. Higher lutein consumption has been linked to a reduced risk of age-related macular disease (ARMD) . Furthermore, lutein supplementation improved visual function in patients with ARMD  and reduced further progression to ARMD in individuals with low dietary lutein intake . Many other beneficial health effects have been reported, including improved cognitive function, decreased risk of cancer and improvement in biomarkers related to cardiovascular health .
Benefits of liposomal Lutein
Lutein has poor aqueous solubility and therefore low oral bioavailability. Lipophilic compounds such as lutein become more bioavailable when they are incorporated into phospholipid carriers [11,12]. Liposomes therefore pose a suitable candidate for a delivery system. Lutein is strongly retained by the liposomal membrane and is hardly released into gastric fluid. The latter is desirable since degradation of the active molecule in the stomach can reduce the amount available for absorption in the intestine [13,14]. In addition, Lutein encapsulated in liposomes showed greater antioxidant activity compared to lutein in suspension .
Benefits of liposomal lutein in combination with DHA
DHA is arguably the most valuable omega 3 fatty acid for vision health [1-3]. DHA plays an important role in eye development while it helps maintain retinal function. Also for DHA the way it is formulated and delivered is crucial to maximize its efficacy in the human body. Both compounds greatly benefit from a phospholipid liposome matrix and synergize each other. LIPOSOMA’s supplement features both Lutein and DHA in an advanced liposomal product that particularly stands out among the wide arsenal of other omega 3- and lutein-containing health supplements in that it is formulated and manufactured to provide the best conditions for the actives to maximize uptake in the intestines and reach the eye. DHA and Lutein are loaded into the liposomes to make them work synergistically, providing a unique combination for vision health.
Liposoma’s Lutein-DHA comes in a uniquely freeze-dried form
While most other DHA- and lutein-containing health supplements are oil-based or provided as an aqueous dispersion, LIPOSOMA’s liposomal DHA-Lutein supplement also features the benefits of a freeze-dried powder formulation for improved storage stability. LIPOSOMA has developed a freeze drying technique for its liposomal supplements that allows both for freezing and drying without damaging the vesicular bilayer structure of the liposome. This means that after reconstitution in a water environment (e.g. in the intestinal lumen) the liposomes reappear the way they were made without chemical or morphological decay.
Freeze drying not only ensures long-term physical and chemical stability but also makes LIPOSOMA’s supplements compatible with so-called Delayed Release capsules that only open after passage through the stomach, avoiding the detrimental gastric environment. This is something any DHA food supplement product can significantly benefit from but this cannot be achieved with most other (oil-based) products, including the DHA-enriched oils. Our supplement is a technologically-superior liposomal DHA-Lutein product in comparison of standard supplements that have poor efficacy due to inadequate absorption and cellular utilization.
With our liposomal supplement we provide you a therapeutic, bioavailable vision health supplement that allows the body to better utilize its numerous benefits that are being studied and documented by many scientists all over the world.
“Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions. “
Liposoma Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules and many other tailored solutions.
Would you like to learn more? Give us a call at 0031 20 237 36 00
 Sommerburg, O., Siems, W.G., Van Kuijk, F.J. (2000). Localization of carotenoids in different eye tissues. BioFactors (Oxford, England) 11(1-2), 3-6.
 Manayi, A., Abdollahi, M., Raman, T., Nabavi, F.S., Habtemariam, S., Daglia, M., Nabavi, S.M. (2016). Lutein and cataract: from bench to bedside. Critical Reviews in Biotechnology, 36(5), 829-839. doi:10.3109/07388551.2015.1049510
 Kijlstra, A., Tian, Y., Kelly, E.R., Berendschot, T.T.J.M. (2012). Lutein: More than just a filter for blue light. Progress in Retinal and Eye Research 31, 303-315.
 Eroglu, A., Harrison E.H. (2013). Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids. Journal of Lipid Research 54(7), 1719-30. doi: 10.1194/jlr.R039537.
 Calvo, M.M. (2005). Lutein: a valuable ingredient of fruit and vegetables. Critical Reviews in Food Science and Nutrition 45(7-8), 671-96.
 Perry, A., Rasmussen, H., Johnson, E. (2009). Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products. Journal of Food Composition and Analysis 22, 9–15.
 Eisenhauer, B., Natoli, S., Liew, G., Flood, V.M. (2017). Lutein and Zeaxanthin- Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients 9, 120. doi:10.3390/nu9020120.
 Richer S, Stiles W, Statkute L, Pulido J, Frankowski J, Rudy D, Pei K, Tsipursky M, Nyland J. (2004). Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 75(4), 216-30.
 Age-Related Eye Disease Study 2 (AREDS2) Research Group. (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 309(19), 2005-15. doi: 10.1001/jama.2013.4997.
 Buscemi, S., Corleo, D., Di Pace, F., Petroni, M.L., Satriano, A., Marchesini, G. (2018). The Effect of Lutein on Eye and Extra-Eye Health. Nutrients 10(9). pii: E1321. doi:10.3390/nu10091321.
 Dahan, A., Duvdevani, R., Shapiro, I., Elmann, A., Finkelstein, E., Hoffman, A. (2008). The oral absorption of phospholipid prodrugs:In vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproicacid conjugate following oral administration. Journal of Controlled Release 126, 1-9.
 McClements, D.J., Li, Y. (2010). Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components. Advances in Colloid and Interface Science 159, 213-228.
 Tan, C., Xue, J., Lou, X., Abbas, S., Guan, Y., Feng, B., Zhang, X., Xia, S. (2014a). Liposomes as delivery systems for carotenoids: comparative studies of loading ability, storage stability and in vitro release. Food & Function 5(6), 1232-40. doi: 10.1039/c3fo60498e.
 Tan, C., Zhang, Y., Abbas, S., Feng, B., Zhang, X., Xia, S. (2014b). Modulation of the carotenoid bioaccessibility through liposomal encapsulation. Colloids and Surfaces B: Biointerfaces 123, 692-700.
 Tan, C., Xue, J., Abbas, S., Feng, B., Zhang, X., Xia, S. (2014c). Liposome as a delivery system for carotenoids: comparative antioxidant activity of carotenoids as measured by ferric reducing antioxidant power, DPPH assay and lipid peroxidation. Journal of Agricultural and Food Chemistry 62(28), 6726-35.
 Harris W.S., Baack M.L. (2015). Beyond building better brains: bridging the docosahexaenoic acid (DHA) gap of prematurity. J Perinatol. 35(1), 1-7.
 Bazan N.G., Musto A.E., Knott E.J. (2011) Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. Mol Neurobiol. 44(2), 216-22.
 Bazan N.G., Molina M.F., Gordon W.C. (2011) Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases. Annu Rev Nutr. 31, 321-51.
Mares J. (2016). Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annual review of nutrition 36, 571–602. doi: 10.1146/annurev-nutr-071715-051110.
Ranard, K. M., Jeon, S., Mohn, E. S., Griffiths, J. C., Johnson, E. J., & Erdman, J. W., Jr (2017). Dietary guidance for lutein: consideration for intake recommendations is scientifically supported. European journal of nutrition, 56(Suppl 3), 37–42. doi: 10.1007/s00394-017-1580-2.