Our unique formulation process and liposome technology provide you with high-end liposomal DHA for brain maintenance
Why take DHA?
Docosahexaenoic acid (DHA) is an important omega 3 fatty acid that plays a role in brain functioning [1-3]. In addition, DHA is beneficial for vision health [1-3], playing a role in eye development, while it helps to maintain retinal function [4]. The beneficial effects on both brain function and vision health is not only true for adults. Indeed, DHA intake by pregnant or breastfeeding mothers is also beneficial for the brain and vision development of their fetus or newborn baby, respectively [5]. This beneficial effect is obtained with a daily intake of 200 mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults of 250 mg [4]. Our unique formulation process and liposome technology provide you with high-end liposomal DHA for brain maintenance.
Liposomal DHA
At LIPOSOMA, we have developed our DHA supplements in a unique, optimal way. Our liposomal DHA product stands out among the wide arsenal of omega 3 fatty acid-containing health supplements in that it holds DHA as a purified free fatty acid encapsulated in a liposome rather than chemically bound as a triglyceride in an oil. In our brain, DHA is also bound to phospholipids and not to triglycerides. The liposomes encapsulating our DHA are small, carefully designed vesicles essentially made of phospholipids that can effectively encapsulate and deliver fatty components such as DHA in their purest form [6].
Besides providing DHA as free fatty acid, LIPOSOMA’s supplement essentially delivers DHA in a clever “assembly kit” by co-encapsulating it in the liposomes with an equal quantity of phospholipid. Thanks to this encapsulation, the intestinal lumen phospholipid is converted into lysophospholipid, providing the other part of the kit. The cells involved in the uptake will then start to reassemble the kit parts, constructing a new DHA-containing phospholipid out of the lyso-part and the free DHA-part delivered by the liposomes, resembling the natural form in which DHA occurs in the brain.
Freeze-dried liposomal DHA
Our freeze-dried liposomal DHA is not only unique in that it is packed in liposomes, but also because this product comes as a dry powder for improved storage stability. LIPOSOMA has developed a freeze drying technique for its liposomal supplements that allows both for freezing and drying without damaging the vesicular bilayer structure of the liposome.
This means that after reconstitution in a water environment (e.g. in the intestinal lumen) the liposomes reappear the way they were made without chemical or morphological changes.
Freeze-drying not only ensures long-term physical and chemical stability, but also makes LIPOSOMA’s supplements compatible with so-called Delayed Release capsules that only open after passage through the stomach, avoiding the detrimental gastric environment. This is something any DHA food supplement product can significantly benefit from, but this cannot be achieved with most other (oil-based) products, including the DHA-enriched oils.
This also has the benefit that our DHA supplements are neutral in taste.
“Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions. “
Liposoma Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
Would you like to learn more? Give us a call at 0031 20 237 36 00
Sources
[1] Harris WS, Baack ML. Beyond building better brains: bridging the docosahexaenoic acid (DHA) gap of prematurity. J Perinatol. 2015; 35(1):1-7.
[2] Bazan NG, Musto AE, Knott EJ. Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. Mol Neurobiol. 2011; 44(2): 216-22.
[3] Bazan NG, Molina MF, Gordon WC. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases. Annu Rev Nutr. 2011; 31: 321-51.
[4] Scientific Opinion on the substantiation of health claims related to docosahexaenoic acid (DHA) and maintenance of normal (fasting) blood concentrations of triglycerides (ID 533, 691, 3150), protection of blood lipids from oxidative damage (ID 630), contr. (2010). EFSA Journal, 8(10), p.1734.
[5] Jensen, C. L., & Lapillonne, A. (2009). Docosahexaenoic acid and lactation. Prostaglandins, leukotrienes and essential fatty acids, 81(2-3), 175-178
[6] Alaarg A, Jordan NY, Verhoef JJ, Metselaar JM, Storm G, Kok RJ. Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment. Int J Nanomedicine. 2016; 11: 5027-5040.