High-quality melatonin, packed in a liposome, providing you with improvement of sleep onset, sleep pattern, and its ability to alleviate symptoms of jet lag.
Why Melatonin?
LIPOSOMA offers white label liposomal melatonin supplements. These supplements include high-quality melatonin, packed in a liposome, providing you with the numerous health effects of melatonin including its improvement of sleep onset, sleep pattern, and its ability to alleviate symptoms of jet lag. Our liposomal melatonin supplements are available as capsules, liquids and as water-dispersible powder. Moreover, we are open to discuss other tailored solutions. The quality of our high-end liposomal melatonin supplements are ensured by our experienced and well-trained manufacturing team and their commitment to scientific excellence.
Melatonin health benefits
Sleep is crucial to a healthy life[1]. Many different medications exist to treat sleep disorders, but these have serious side effects including dependency and cognitive impairment [2,3]. Melatonin supplementation on the other hand is a safe and effective method to contribute to a faster sleep onset and normal sleep patterns [4,5]. Melatonin is a naturally produced hormone that regulates the sleep-wake cycle [3]. It is well tolerated and does not induce dependence [3]. Furthermore, studies report that people using melatonin experience less severe jet lags, better self-recorded mood ratings and sleep parameters [6].
Why liposomal Melatonin?
Although melatonin is relatively soluble in aqueous solvents [7], the bioavailability of oral melatonin is relatively low. This is due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract [8,9,] . Standard products feature melatonin in free form in which it is subject to these biological challenges. By encapsulating melatonin in liposomes and protecting it from premature degradation while enhancing its intestinal absorption, our product partially overcomes these issues, increasing the chance of it reaching the site of action [10].
“Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.”
LIPOSOMA Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
Would you like to learn more? Give us a call at 0031 20 237 36 00
Sources
[1] Xie, Z., Chen, F., Li, W. A., Geng, X., Li, C., Meng, X., … & Yu, F. (2017). A review of sleep disorders and melatonin. Neurological research, 39(6), 559-565.
[2] Auld, F., Maschauer, E. L., Morrison, I., Skene, D. J., & Riha, R. L. (2017). Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Medicine Reviews, 34, 10-22.
[3] Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-analysis: melatonin for the treatment of primary sleep disorders. PloS one, 8(5), e63773.
[4] van Geijlswijk, I. M., Korzilius, H. P., & Smits, M. G. (2010). The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep, 33(12), 1605-1614.
[5] Thottakam, B. M., Webster, N. R., Allen, L., Columb, M. O., & Galley, H. F. (2020). Melatonin Is a Feasible, Safe, and Acceptable Intervention in Doctors and Nurses Working Nightshifts: The MIDNIGHT Trial. Frontiers in psychiatry, 11, 872.
[6] Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008). Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel Medicine and Infectious Disease, 6(1-2), 17-28.
[7] Shida, C. S., Castrucci, A. D., & Lamy‐Freund, M. T. (1994). High melatonin solubility in aqueous medium. Journal of pineal research, 16(4), 198-201.
8] Harpsøe, N. G., Andersen, L. P. H., Gögenur, I., & Rosenberg, J. (2015). Clinical pharmacokinetics of melatonin: a systematic review. European journal of clinical pharmacology, 71(8), 901-909.
[9] Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., & Fougerou, C. (2017). Melatonin: pharmacology, functions and therapeutic benefits. Current neuropharmacology, 15(3), 434-443.
[10] Bozzuto, G., & Molinari, A. (2015). Liposomes as nanomedical devices. International journal of nanomedicine, 10, 975.