Melatonin can be a safe and effective method to improve sleep initiation, duration and quality
Melatonin health benefits
Sleep is crucial to a healthy life; inadequate sleep can lead to serious impairments in daily tasks and increase the risk for obesity, depression and heart disease. Many different medications exist to treat sleep disorders, but these have serious side effects including dependency and cognitive impairment. Melatonin supplementation on the other hand is a safe and effective method to improve sleep initiation, duration and quality. Melatonin is a naturally produced hormone that regulates the sleep-wake cycle. It is well tolerated and unlikely to create dependence. People with sleep disorders or differently timed sleep rhythms, for example due to shift work or jet lag, may therefore benefit from Melatonin treatment [1,2]. Melatonin has also been shown beneficial in the treatment of other diseases including liver diseases , eczema  and bipolar disorders .
Melatonin is a naturally produced hormone that regulates the sleep-wake cycle. Inadequate sleep can lead to serious impairments in daily tasks and increase the risk for obesity, depression and heart disease. Supplementation of Melatonin safely and effectively improves sleep initiation, duration and quality. Melatonin lacks serious side effects and is far less likely to create dependency compared to other medications used to treat sleep disorders. In addition, Melatonin therapy can help stabilize the sleep-wake rhythm in people that are unable to synchronize their cycle with the environmental day-night cycle (due to jet lag or shift work for example) [1,2]. It has also been shown beneficial in the treatment of other diseases including liver diseases , eczema  and bipolar disorders .
Why liposomal Melatonin?
Although melatonin is more soluble in aqueous solvents , the bioavailability of oral Melatonin is relatively low. This is due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract [7,8]. Current Melatonin products are non-encapsulated and subject to these biological challenges. Our liposomal Melatonin, partially overcomes these issues and thereby increases the efficacy. Liposomes are highly stable carriers that offer protection from degradative enzymes . In addition, they are more easily absorbed by intestinal cells compared to non-carrier formulations [10,11].
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Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
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 Xie, Z., Chen, F., Li, W.A., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W., Yu, F. (2017). A review of sleep disorders and melatonin. Neurological Research 6, 559-565. doi: 10.1080/01616412.2017.1315864.
 Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology 175(16), 3190-3199. doi: 10.1111/bph.14116. Epub 2018 Jan 15.
 Bonomini F, Borsani E, Favero G, Rodella LF, Rezzani R. (2018). Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases. Nutrients. 2018 Aug 21;10(9). pii: E1135. doi: 10.3390/nu10091135.
 Taghavi Ardakani, A., Farrehi, M., Sharif, M.R., Ostadmohammadi, V., Mirhosseini, N., Kheirkhah, D., Moosavi, S.G.A., Behnejad, M., Reiter, R.J., Asemi, Z. (2018). The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial. Pediatric Allergy and Immunology 29(8), 834-840. doi: 10.1111/pai.12978.
 Geoffroy, P.A., Etain, B., Franchi, J.A., Bellivier, F., Ritter, P. (2015). Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Current Pharmaceutical Design 21(23), 3352-8.
 Shida, C.S., Castrucci, A.M., Lamy-Freund, M.T. (1994). High melatonin solubility in aqueous medium. Journal of Pineal Research 16(4), 198-201.
 Harpsøe, N.G., Andersen, L.P., Gögenur, I., Rosenberg, J. (2015). Clinical pharmacokinetics of melatonin: a systematic review. European Journal of Clinical Pharmacology 71(8), 901-9. doi: 10.1007/s00228-015-1873-4.
8] Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., Fougerou, C. (2017). Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology 15(3), 434-443. doi:10.2174/1570159X14666161228122115.
 Bozzuto, G., Molinari, A. (2015). Liposomes as nanomedical devices. International Journal of Nanomedicine 10, 975-99. doi: 10.2147/IJN.S68861.
 Hafner, A., Lovrić, J., Voinovich, D., Filipović-Grcić, J. (2009). Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers. International Journal of Pharmaceutics 381(2), 205-13. doi: 10.1016/j.ijpharm.2009.07.001.
Zhang, Q., Ou, C., Ye, S., Song, X., & Luo, S. (2017). Construction of nanoscale liposomes loaded with melatonin via supercritical fluid technology. Journal of microencapsulation, 34(7), 687–698.