In addition to the roles vitamin K2 and D3 play in bone health, the interplay of these vitamins is suggested to be beneficial for cardiovascular health
Liposomal vitamin K2-D3
Liposoma offers white label liposomal vitamin D3+K2 supplements. These supplements include high-quality vitamins, packed in liposomes, providing you with numerous health effects. Both vitamins together play a central role in calcium metabolism, bone health and are suggested to be important in cardiovascular health as well. In addition, currently a lot of research is conducted on the possible link between low levels of these vitamins, and poor disease outcomes in COVID-19 patients. Our liposomal vitamin D3+K2 supplements help maintain D3 and K2 levels at the right level. Supplements are available as capsules, liquids and a water-soluble powder. Moreover, we are open to discuss other tailored solutions. Our high-end liposomal D3+K2 supplements are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Health benefits vitamin D3-K2
Vitamin D3 and K2 are a key synergistic combination and together play a central role in calcium metabolism  and bone health [2,3]. Vitamin D is important for the uptake of calcium and phosphorus from the intestine, which are the main ingredients in healthy bones and teeth . Furthermore, vitamin D promotes the synthesis of vitamin K2-dependent proteins that bind calcium into the bones , illustrating the role both vitamins have in proper calcium bone metabolism. It is well known that vitamin D deficiency leads to osteoporosis, and rickets in children . Deficiencies of vitamin K2 are associated with the so-called “calcium-paradox”. In this clinical phenomenon, calcium is depleted from the bone and accumulating in vessel walls, resulting in both osteoporosis and atherosclerosis . Indeed, besides the role they play in bone health, both vitamins together are suggested to be important in cardiovascular health as well . It is important to state that these benefits come on top of the well-known beneficial effects of vitamin D3 on immune system health and muscle strength  and on premenstrual syndrome symptoms . Vitamin K2 plays an important role in blood clotting , and has been suggested to play a role in preventing diabetes type 2 .
Supplements with vitamin D3 and K2
Poor bone health is a common problem in our ageing society. In 2018, there were almost half a million osteoporosis patients in the Netherlands . The number of patients increases with age, and osteoporosis is more common in women . Supplementation with vitamin K2 in postmenopausal women was shown to improve bone health , while vitamin D in combination with calcium is reported to reduce bone fracture rates in the elderly [11,12]. Evidence now points at the synergistic effects of combining both vitamins, providing optimal benefit to this growing population of elderly . Furthermore, children and adolescents might benefit from both vitamin D3 and K2 together, with this combination shown to be critical in bone formation [2,3]. Finally, as the combination of low vitamin D and K levels is associated with increased blood pressure, and a trend for increased hypertension risk, science suggests that cardiovascular health can be greatly improved by supplementation with the combination of vitamin D3 and K2 .
Vitamin D3-K2 and Covid-19
In addition to the previously mentioned beneficial effects of both vitamins alone and in combination, a recent study has suggested a link between low vitamin K levels and COVID-19, and poorer health outcomes of this disease . Furthermore, circumstantial evidence points out the potential contribution of both vitamins to lower mortality rates of COVID-19 . A meta-analysis has shown that vitamin D supplementation is safe and effective in the prevention of acute respiratory tract infections . Moreover, a pilot-study showed significantly improved health outcomes in patients with COVID-19 that received supplementation with calcifediol, an activated form of vitamin D3 . Research is ongoing on the relation between vitamin K2, vitamin D3 and COVID-19, but for now it can be hypothesized that supplementation of vitamin D3 and K2 might help prevent COVID-19 and improve disease development [15, 18]. Especially, people who are at risk of vitamin D3 and K level deficiencies should consider vitamin D3 and K2 supplementation.
The benefits of liposomal vitamin D3 and K2
As both vitamin D3 and K2 are fat-soluble components, sufficient uptake from the gastro-intestinal tract can pose a challenge for the body. Research suggests that uptake of fat-solubles can be increased by encapsulating them in a liposome . Besides increasing absorption, the liposome protects the integrity and functionality of the encapsulated bioactives, in this case vitamin D3 and K2 . With improved bioavailability, liposomal vitamin D3 and K2 supplements can be considered more effective than both substances provided in regular supplements .
“Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions. “
Liposoma Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
Would you like to learn more? Give us a call at 0031 20 237 36 00
 Van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The synergistic interplay between vitamins D and K for bone and cardiovascular health: a narrative review. International journal of endocrinology, 2017.
 Holick, M. F. (2006). Resurrection of vitamin D deficiency and rickets. The Journal of clinical investigation, 116(8), 2062-2072.
 Myneni, V. D., & Mezey, E. (2017). Regulation of bone remodeling by vitamin K2. Oral diseases, 23(8), 1021-1028.
 Flore, R., Ponziani, F. R., Di Rienzo, T. A., Zocco, M. A., Flex, A., Gerardino, L., … & Chierici, E. (2013). Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. Eur Rev Med Pharmacol Sci, 17(18), 2433-2440.
 Van Ballegooijen, A. J., Cepelis, A., Visser, M., Brouwer, I. A., Van Schoor, N. M., & Beulens, J. W. (2017). Joint association of low vitamin D and vitamin K status with blood pressure and hypertension. Hypertension, 69(6), 1165-1172.
 Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281.
 Fatemi, M., Allahdadian, M., & Bahadorani, M. (2019). Comparison of serum level of some trace elements and vitamin D between patients with premenstrual syndrome and normal controls: A cross-sectional study. International Journal of Reproductive Biomedicine, 17(9), 647.
 Li, Y., peng Chen, J., Duan, L., & Li, S. (2018). Effect of vitamin K2 on type 2 diabetes mellitus: A review. Diabetes Research and Clinical Practice, 136, 39-51.
 Nielen, M.M.J., Poos, M.J.J.C., van den Bergh, J.P., Zillikens, M.C., Jager, F.F. (2019). Osteoporose→ Cijfers & Context→ Huidige situatie. Volksgezondheidenzorg.info. Retrieved on 11-08-2020 from https://www.volksgezondheidenzorg.info/onderwerp/osteoporose/cijfers-context/huidige-situatie#node-prevalentie-osteoporose-huisartsenpraktijk.
 Knapen, M. H. J., Drummen, N. E., Smit, E., Vermeer, C., & Theuwissen, E. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 24(9), 2499-2507.
 Dawson-Hughes, B., Harris, S. S., Krall, E. A., & Dallal, G. E. (1997). Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. New England Journal of Medicine, 337(10), 670-676.
 Chapuy, M. C., Arlot, M. E., Duboeuf, F., Brun, J., Crouzet, B., Arnaud, S., … & Meunier, P. J. (1992). Vitamin D3 and calcium to prevent hip fractures in elderly women. New England journal of medicine, 327(23), 1637-1642.
 Ushiroyama, T., Ikeda, A., & Ueki, M. (2002). Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas, 41(3), 211-221.
 Dofferhoff, A. S., Piscaer, I., Schurgers, L. J., Visser, M. P., van den Ouweland, J. M., de Jong, P. A., … & Maassen, C. (2020). Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19. Clinical Infectious Diseases.
 Goddek, S. (2020). Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate. International Journal of Infectious Diseases.
 Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., … & Goodall, E. C. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. bmj, 356.
 Castillo, M. E., Costa, L. M. E., Barrios, J. M. V., Díaz, J. F. A., Miranda, J. L., Bouillon, R., & Gomez, J. M. Q. (2020). Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. The Journal of steroid biochemistry and molecular biology, 105751.
 Ali, N. (2020). Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of infection and public health.
 Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., … & Nejati-Koshki, K. (2013). Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), 102.
 Chaves, M. A., Oseliero Filho, P. L., Jange, C. G., Sinigaglia-Coimbra, R., Oliveira, C. L. P., & Pinho, S. C. (2018). Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D3. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 549, 112-121.
 Fricker, G., Kromp, T., Wendel, A., Blume, A., Zirkel, J., Rebmann, H., … & Müller-Goymann, C. (2010). Phospholipids and lipid-based formulations in oral drug delivery. Pharmaceutical research, 27(8), 1469-1486.