Our clever combination of liposomal CBD and Melatonin, safely and effectively contributes to a faster sleep initiation
Health benefits liposomal CBD & Melatonin
Our liposomal supplement that addresses anxiety and sleep quality features a clever combination of CBD and Melatonin which ensures maximal absorption of CBD as a result of our proprietary formulation process and liposome technology.
What is CBD?
Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects [1].
Why is Melatonin added?
Melatonin is a naturally produced hormone that helps maintain normal sleep patterns. Supplementation of melatonin safely and effectively contributes to a faster sleep initiation. In addition, melatonin therapy can help alleviate the symptoms of a jet lag, as people using melatonin report better self-recorded mood ratings and sleep parameters [2].
Limitations of current CBD and Melatonin products
CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products [3]. Although melatonin is more soluble [4] the bioavailability of oral melatonin is still relatively low. This is due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract [5, 6]. Thus, there is a clear need for a product that leads to improved absorption of both active ingredients combined.
Increased efficacy
Our liposomal CBD & Melatonin supplement makes improved absorption in the gut possible. Liposomes are small, carefully designed phospholipid vesicles that form very stable dispersions in water [7]. The phospholipids constitute a bilayer structure in which the CBD and melatonin molecules can be safely kept dissolved, protecting them from degradative enzymes [8]. In addition, liposomes are more easily absorbed by intestinal epithelial cells compared to non-carrier formulations [9, 10].
What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes. This ensures maximal efficiency in body uptake and therapeutic benefit.
“Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions. “
LIPOSOMA Nutraceuticals; experts in liposomes
LIPOSOMA manufactures branded and white label liposomal supplements.
Our high-end liposomal nutraceuticals are guaranteed by the academic qualifications of our team and its commitment to scientific excellence.
Our liposome technology offers many advantages for nutritional supplement producers, the food sector and consumers. Our liposomal vitamins and other nutraceuticals are available as raw materials, capsules, liquids and many other tailored solutions.
Would you like to learn more? Give us a call at 0031 20 237 36 00
Sources
[1] Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V., & Mechoulam, R. (2009). Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in pharmacological sciences, 30(10), 515-527.
[2] Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008). Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel Medicine and Infectious Disease, 6(1-2), 17-28
[3] Zgair, A., Wong, J. C., Lee, J. B., Mistry, J., Sivak, O., et al. (2016). Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American Journal of Translational Research, 8(8), 3448.
[4] Shida, C.S., Castrucci, A.M., Lamy-Freund, M.T. (1994). High melatonin solubility in aqueous medium. Journal of Pineal Research 16(4), 198-201.
[5] Harpsøe, N.G., Andersen, L.P., Gögenur, I., Rosenberg, J. (2015). Clinical pharmacokinetics of melatonin: a systematic review. European Journal of Clinical Pharmacology 71(8), 901-9. doi: 10.1007/s00228-015-1873-4.
[6] Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., Fougerou, C. (2017). Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology 15(3), 434-443.
[7] Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., et al. (2013). Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), 102.
[8] Bozzuto, G., Molinari, A. (2015). Liposomes as nanomedical devices. International Journal of Nanomedicine 10, 975-99.
[9] Hafner, A., Lovrić, J., Voinovich, D., Filipović-Grcić, J. (2009). Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers. International Journal of Pharmaceutics 381(2), 205-13. doi: 10.1016/j.ijpharm.2009.07.001.
[10] Liu W, Ye A, Han F, Han J. (2019). Advances and challenges in liposome digestion: Surface interaction, biological fate, and GIT modeling. Advances in Colloid and Interface Science 263, 52-67. doi: 10.1016/j.cis.2018.11.007.
Further readings
Andersen, L. P., Werner, M. U., Rosenkilde, M. M., Harpsøe, N. G., Fuglsang, H., Rosenberg, J., & Gögenur, I. (2016). Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. BMC pharmacology & toxicology 17, 8. doi: 10.1186/s40360-016-0052-2.
Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R. Y., Xu, D. P., & Li, H. B. (2017). Dietary Sources and Bioactivities of Melatonin. Nutrients 9(4), 367. doi: 10.3390/nu9040367